Henrietta Lacks died in 1951 of an aggressive adenocarcinoma of the cervix. A tissue biopsy obtained for diagnostic evaluation yielded additional tissue for Dr George O. Gey’s tissue culture laboratory at Johns Hopkins (Baltimore, Maryland). The cancer cells, now called HeLa cells, grew rapidly in cell culture and became the ﬁrst human cell line. HeLa cells were used by researchers around the world. However, 20 years after Henrietta Lacks’ death, mounting evidence suggested that HeLa cells contaminated and overgrew other cell lines. Cultures, supposedly of tissues such as breast cancer or mouse, proved to be HeLa cells. We describe the history behind the development of HeLa cells, including the ﬁrst published description of Ms Lacks’ autopsy, and the cell culture contamination that resulted. The debate over cell culture contamination began in the 1970s and was not harmonious. Ultimately, the problem was not resolved and it continues today. Finally, we discuss the philosophical implication of the immortal HeLa cell line.
Henrietta's Tumor (11 minutes)
The Way of All Flesh by Adam Curtis (1 hour)
In 1998, Modern Times: The Way of All Flesh, a one-hour BBC documentary on Henrietta Lacks and HeLa directed by Adam Curtis, won the Best Science and Nature Documentary at the San Francisco International Film Festival.